Multiwalled carbon nanotubes effect on the bioavailability of artemisinin and its cytotoxity to cancerous cells |
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Authors: | Behzad Rezaei Najmeh Majidi Shokoofe Noori Zuhair M Hassan |
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Institution: | (1) Department of Chemistry, Isfahan University of Technology, Isfahan, 84156-83111, Islamic Republic of Iran;(2) Department of Biochemistry, School of Medical Sciences, Tarbiat Modares University, Tehran, Islamic Republic of Iran |
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Abstract: | Artemisinin regarded as one of the most promising anticancer drugs can bind to DNA with a binding constant of 1.04 × 104 M−1. The electrochemical experiments indicated that for longer incubation time periods, the reduction peak current of artemisinin
on carbon nanotube modified electrode increases. Therefore, the uptake of drug molecules from a solution into CNTs will be
achieved automatically by adsorption of 88.7% of artemisinin onto carbon nanotubes surface without alteration in drug properties.
Hence, capability of carbon nanotubes to have synergistic effect on the bioavailability of artemisinin was investigated. Experimental
tests on K562 cancer cell lines growth by MTT assay proved that multi-walled carbon nanotubes can enhance the cytotoxity of
artemisinin to the targeted cancer cells with unprecedented accuracy and efficiency. The IC50 values were 65 and 35 μM for artemisinin and artemisinin loaded on multi-walled carbon nanotubes, respectively; demonstrating
that artemisinin loaded on multi-walled carbon nanotubes is more effective in inhibition of cancer cell lines growth. |
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