Catalytic enantioselective Conia-ene reaction |
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| Authors: | Corkey Britton K Toste F Dean |
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| Institution: | Department of Chemistry, University of California, Berkeley, California 94720, USA. |
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| Abstract: | An enantioselective intramolecular Conia-ene reaction of beta-dicarbonyl compounds and alkynes to afford methylene cyclopentanes is described. The reaction employs a DTBMSegphos-Pd(II)/Yb(III) dual catalyst system that allows for the asymmetric synthesis of all-carbon quaternary centers and generates a product containing an alkene that can be further manipulated. |
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