Isomerization kinetics of panipenem in aqueous solution |
| |
Authors: | Ito Nobuya Suzuki Masahiko Kusai Akira Takayama Kozo |
| |
Institution: | Pharmaceutical Development Laboratories, Sankyo Co., Ltd., 1-12-1 Shinomiya, Kanagawa 254-0014, Japan. noitou@sankyo.co.jp |
| |
Abstract: | The isomerization kinetics of panipenem (INN: (+)-(5R,6S)-3-(S)-1-(acetimidoylpyrrolidin-3-yl)thio]-6-(R)-hydroxyethyl]-7-oxo-1-azabicyclo3.2.0]hept-2-ene-2-carboxylic acid, CAS No. 87726-17-8) in aqueous solution were investigated. An equilibrium between the Z-form and E-form was observed, and it was found that the isomerization rates were affected by the pH of the solution. Under acidic conditions, the isomerization rates were small. However, the isomerization rates were increased with the pH value. This phenomenon resulted from the extent of proton dissociation from the acetimidoyl group. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|