Identification of target organs of copper nanoparticles with ICP-MS technique |
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| Authors: | Zhen Chen Huan Meng Hui Yuan Gengmei Xing Chunying Chen Feng Zhao Yun Wang Chengcheng Zhang Yuliang Zhao |
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| Institution: | (1) Laboratory for Bio-Environmental Health Sciences of Nanoscale Materials, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, P.R. China;(2) The Graduate University of Chinese Academy of Sciences, Beijing, 100049, P.R. China;(3) National Center for Nanoscience and Nanotechnology, China, Beijing, 100081, P.R. China |
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| Abstract: | Nanosized copper particles are widely used in fields of lubricants, polymers/plastic, metallic coating and ink. Recently,
we found that copper particles in different sizes can lead to different toxicological effects. To clarify the target organs
of copper particles of different sizes, the inductively coupled plasma mass spectroscopy (ICP-MS) was employed to evaluate
the distribution of copper in different organs of mice after a single dose oral exposure. The results suggest that the main
target organs for copper nanoparticles are kidney, liver and blood. Liver is the main damaged organ. |
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