Dynamics of spiral waves in a cardiac electromechanical model with a local electrical inhomogeneity |
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| Authors: | Luca Mesin |
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| Institution: | 1. Department of Radiation Oncology, The First Hospital of China Medical University, Shenyang, China;2. Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas;3. Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas;1. Graduate School of Science, Chiba University, Chiba, Japan;2. The Institute of Statistical Mathematics, Tokyo, Japan;3. Center for Environmental Remote Sensing, Chiba University, Chiba, Japan;4. Department of Geophysics, School of Earth and Space Sciences, Peking University, Beijing, China;1. Department of Radiation Oncology, The First Hospital of China Medical University, China;2. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, USA;3. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, USA |
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| Abstract: | Joint effect of electrical heterogeneity (e.g. induced by ischemia) and mechanical deformation is investigated for an anisotropic, quasi–incompressible model of cardiac electromechanical coupling (EMC) using the active strain approach and periodic boundary conditions. Three local inhomogeneities with different geometry are simulated. Under a specific stimulation protocol, the heterogeneities are able to induce spirals. The interplay between the dimension of the electrical inhomogeneity, the EMC and the mechano-electrical feedback provided by the stretch activated current (SAC) determines the dynamics of the spiral waves of excitation, which could extinguish (in the case of low SAC), or be stable (with the tip rotating inside the inhomogeneity), or drift and be annihilated (in the case of high SAC). |
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