Shape selectivity in embedded polar group stationary phases for liquid chromatography

Seven columns with embedded polar functionality were evaluated for use in liquid chromatography with a focus on molecular shape recognition. Tests based on Standard Reference Material 869b Column Selectivity Test Mixture for Liquid Chromatography and the Tanaka test indicate that only two of the phases are slightly shape selective at 20 °C. The shape recognition characteristics of the phases appear to be directly related to the density of the embedded polar ligands and the temperature of the separation, consistent with trends observed with conventional hydrocarbon phases.

Catherine A. RimmerEmail:

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Catherine Rimmer   is a Research Chemist at the National Institute of Standards and Technology where she began as a National Research Council Postdoctoral Fellow. Her research efforts are currently directed towards an improved understanding of chromatographic processes to advance the “state of the art” in chemical metrology.