Radiopharmaceuticals |
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Authors: | E J Knust H -J Machulla P L Zabel Chr Astfalk U Schmidt |
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Institution: | (1) Universitätsklinikum, Institut für Medizinische Strahlenphysik und Strahlenbiologie, D-4300 Essen, FRG |
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Abstract: | By nucleophilic isotope exchange, 6-123I-nicotinic acid diethylamide (6-123I-NADA) was synthesized in a solution of the starting compound and catalytic amounts of CuCl in acetic acid. After purification by high pressure liquid chromatography radiochemical yields up to 97% could be obtained within 10 minutes. In mice the radioactivity was rapidly accumulated in the brain reaching the maximum (4.16%/g) 0.5 minutes after i.v. injection and eliminated by a fast and a slow phase. At the maximum of accumulation the brain/blood ratio was 1.21, decreasing to less than 0.15 already after one hour. |
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