Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer |
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| Authors: | Yingying Jin Dalong Ni Jiawen Zhang Fang Han Jing Wang Lu Gao Hua Zhang Yanyan Liu Zhaowen Cui Zhenwei Yao Xiaoyuan Feng Wenbo Bu |
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| Institution: | 1. Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China;2. State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China;3. Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, P. R. China |
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| Abstract: | Colon cancer (CC) is one of the most common intestinal malignancies and is difficult to detect in its early stage by magnetic resonance imaging (MRI) with currently used contrast agents (CAs). The development of targeted CAs contributes to the early diagnosis of CC and thereby enables early intervention and timely therapy. Considering the outstanding performance of upconversion nanoprobes (UCNPs) in high‐performance MR and fluorescence imaging, a new type of nanoprobes with considerably enhanced imaging performance is developed herein. Carcinoembryonic antigen (CEA) antibody is conjugated onto the surface of UCNPs to achieve the targeted imaging of early CC tumors, which overexpress CEA. Both toxicity tests and histological/hematological examinations demonstrate the excellent biocompatibility of these CC‐targeting nanoprobes, which possess great potential for clinical application in the early diagnosis of CC. |
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| Keywords: | colon cancer magnetic resonance imaging targeted imaging upconversion nanoprobes |
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