Renal Clearable Luminescent WSe2 for Radioprotection of Nontargeted Tissues during Radiotherapy |
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Authors: | Haixia Liu Junying Wang Yaqi Jing Jiang Yang Xueting Bai Xiaoyu Mu Fujuan Xu Xuhui Xue Lingfang Liu Yuan‐Ming Sun Qiang Liu Haitao Dai Changlong Liu Xiao‐Dong Zhang |
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Affiliation: | 1. Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, Institute of Advanced Materials Physics, School of Sciences, Tianjin University, Tianjin, China;2. Environment, Energy and Natural Resources Center, Department of Environmental Science and Engineering, Fudan University, Shanghai, China;3. Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China;4. Tianjin Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, China |
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Abstract: | High‐energy ionizing radiation is widely used in medical diagnosis and cancer radiation therapy. However, high‐energy radiation can also impose significant damages in healthy tissues during medical treatments via direct DNA damages and indirect damages from production of reactive oxygen species (ROS). Therefore, it is urgent to develop highly effective radioprotectants with low toxicities that can meet the increasing needs for alleviating the adverse effects from cancer radiation therapy and nuclear emergency. In this work, strongly catalytic ultrasmall (sub‐5 nm) cysteine‐protected WSe2 dots are employed to protect healthy tissues against radiation via diminishing radiation‐induced free radicals. The WSe2 dots with high surface activities can recover radiation‐induced DNA damages and eliminate the excessive ROS generated from radiation. In vivo experiments confirm that the survival rate of mice treated with WSe2 dots is significantly elevated with radiation damages postponed under exposure to high‐dose ionizing radiation. Furthermore, the free radicals in major organs and hematological system can be appreciably omitted, suggesting their unique role as free radical scavengers. These WSe2 dots in ultrasmall size show rapid renal clearance of ≈74% injection dose via urine excretion in 24 h and do not cause any apparent toxicity in vivo for up to 30 d. |
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Keywords: | radiation protection WSe2 renal clearance photoluminescence reactive oxygen species |
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