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Multifunctional Hybrids Based on 2D Fluorinated Graphene Oxide and Superparamagnetic Iron Oxide Nanoparticles |
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| Authors: | Sruthi Radhakrishnan Parambath M. Sudeep Jun Hyoung Park Cristiano F. Woellner Kierstein Maladonado Douglas S. Galvao Benny Abraham Kaipparettu Chandra Sekhar Tiwary Pulickel M. Ajayan |
| Affiliation: | 1. Department of Materials Science and Nano Engineering, Rice University, Houston, TX, USA;2. Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada;3. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA;4. Applied Physics Department, State University of Campinas – UNICAMP, Campinas, Sao Paulo, Brazil;5. Small Animal Imaging Facility, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;6. Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA |
| Abstract: | Carbon‐based nanomaterials have garnered a lot of attention in the research of yesteryear. Here this study reports a composite based on fluorinated graphene oxide—a multifunctional subsidiary of graphene; and iron oxide nanoparticles as a contrast agent for magnetic resonance imaging (MRI). Extensive structural and functional characterization is carried out to understand composite behavior toward biotoxicity and its performance as a contrast agent. The electron withdrawing fluorine group decreases the charge transfer to iron oxide increasing the magnetic saturation of the composite thus enhancing the contrast. The interaction of paramagnetic and superparamagnetic systems yields a superior contrast agent for MRI and fluorescent imaging. |
| Keywords: | fluorescence imaging fluorinated graphene oxide magnetism in 2D MRI imaging multimodal agents |