The Inhibition Effect of Graphene Oxide Nanosheets on the Development of Streptococcus mutans Biofilms |
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| Authors: | Jianliang He Xiaodan Zhu Zhengnan Qi Lihua Wang Ali Aldalbahi Jiye Shi Shiping Song Chunhai Fan Min Lv Zisheng Tang |
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| Affiliation: | 1. Department of Endodontics, Shanghai Research Institute of Stomatology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;2. Department of Oral Medicine, Shanghai Stomatological Hospital, Shanghai, China;3. Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China;4. Chemistry Department, King Saud University, Riyadh, Saudi Arabia;5. UCB Pharma, Slough, UK |
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| Abstract: | Bacterial biofilms play a critical role in dental pathogenic mechanisms due to their ability to tolerate many traditional antibacterial agents. Thus, it is crucial to find effective methods to inhibit the occurrence and development of biofilms. Recently, graphene oxide (GO) nanosheets have become a promising antibacterial nanomaterial for use in various applications. This study focuses on the effect of GO nanosheets on the development of Streptococcus mutans biofilms. It is found that GO nanosheets are highly effective at inhibiting the formation of bacterial biofilms at concentrations ranging from low to high in early development stages. After GO treatment, the ratio of living cells in the biofilm decreases significantly, and the biofilm structure is destroyed. In contrast, GO has a minimal effect on mature biofilms. |
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| Keywords: | biofilm formation extracellular polymeric substances (EPS) graphene oxide Streptococcus mutans biofilms |
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