复方解热镇痛药的毛细管胶束电动色谱快速分析

研究了用毛细管胶束电动色谱快速测定解热镇痛药复方阿司匹林（APC）中阿司匹林（AS），非那西丁（PH），咖啡因（CA）及复方扑热息痛（PAC）中扑息痛（PA），AS，CA含量的方法，使用长37cm（有效长度30cm)内径75um的石英毛细管，＋20kV分离电压，在PH8．65的9mmol.L^-1Na2B4O7-13mmol.L^-1KH2PO4(内含60mmol.L^-1)SDSt 2%乙醇）缓冲溶液中，同一制剂中的三组分可在4．5min内完全分离，用紫外检测器在214nm处检测，外标法定量，测定4组分的相对标准偏差在0．84％－1．84％之间，回收率在99－104％之间，所建立的方法应用于复方阿司匹林片和复方扑热息痛片的成分分析，结果令人满意。

Fast determination of active ingredients in compound antipyretic analgesic tablets by micellar electrokinetic capillary chromatography

A micellar\|electrokinetic\|capillary\|chromatographic approach (MECC) for fast determination of aspirin (AS), phenacetin(PH), caffeine(CA) and paracetamol(PA) in pharmaceutical preparations has been developed. Using a 37cm(effective length 30cm)~{!A~}75~{&L~}m i.d. fused\|quartz capillary and an applied voltage of 20kV, MECC is performed in 9 mmol\5L\+\{-1\} borax\|13 mmol\5L\+\{-1\} KH\-2PO\-4 buffer solution (pH8.65) containing 60 mmol\5L\+\{-1\} SDS and 2% alcohol. The four active ingredients are completely separated within 4.5 minutes, and quantified with UV\|detector at 214nm by external standard calibration. Relative standard deviation(RSD) for determining the four components holds in the range in 0.84%~{!+~}1.84%, while the recovery rate obtained in spike\|recovery test is in the range of 99%~{!+~}104%. The developed method can be successfully applied to the determining the active ingredients in compound aspirin tablet and compound paracetamal tablet.