Cobalt(II) and cobalt(III) dipicolinate complexes: solid state,solution, and in vivo insulin-like properties |
| |
Authors: | Yang Luqin Crans Debbie C Miller Susie M la Cour Agnete Anderson Oren P Kaszynski Peter M Godzala Michael E Austin LaTanya D Willsky Gail R |
| |
Institution: | Department of Chemistry, College of Natural Sciences, Colorado State University, Fort Collins, CO 80523-1872, USA. |
| |
Abstract: | The synthesis and characterization of Co(II) and Co(III) 2,6-pyridinedicarboxylate (dipic(2-)) complexes are reported. Solid-state X-ray characterizations were performed on Co(H(2)dipic)(dipic)].3H(2)O and Co(dipic)(mu-dipic)Co(H(2)O)(5)].2H(2)O. Two coordination modes not previously observed in dipicolinate transition metal complexes were observed in these complexes; one involves metal coordination to the short C-O (C=O) bond, and the other involves metal coordination to a protonated oxygen atom. Solution studies, including paramagnetic NMR and UV-vis spectroscopy, were done showing the high stability and low lability of the Co(III) complex, whereas the Co(II) complexes exhibited ligand exchange in the presence of excess ligand. The Co(dipic)(2)](2-) complex has pH dependent lability and in this regard is most similar to the VO(2)dipic](-) complex. The Co(dipic)(2)](2-) was found to be effective in reducing the hyperlipidemia of diabetes using oral administration in drinking water in rats with STZ-induced diabetes. Oral administration of VOSO(4) was used as a positive control for metal efficacy against diabetes. In addition to providing a framework to evaluate structure-function relationships of various transition metal complexes in alleviating the symptoms of diabetes, this work describes novel aspects of structural and solution cobalt chemistry. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|