Development of a rapid,room-temperature dynamic kinetic resolution for efficient asymmetric synthesis of alpha-aryl amino acids |
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Authors: | Hang Jianfeng Li Hongming Deng Li |
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Institution: | Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110, USA. |
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Abstract: | reaction: see text] A rapid, highly efficient and general dynamic kinetic resolution (DKR) of racemic alpha-aryl UNCAs with the dual-function catalysis of modified cinchona alkaloid was accomplished at room temperature. This DKR led to the development of a highly enantioselective catalytic method for the practical synthesis of a wide range of alpha-aryl and alpha-heteroaryl amino acids in 89-92% ee and 86-95% yield from racemic UNCAs. |
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