Application of high-field NMR and cryogenic probe technologies in the structural elucidation of poecillastrin a,a new antitumor macrolide lactam from the sponge poecillastra species |
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| Authors: | Rashid Mohammad A Gustafson Kirk R Crouch Ronald C Groweiss Amiram Pannell Lewis K Van Que N Boyd Michael R |
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| Institution: | Molecular Targets Drug Discovery Program, Center for Cancer Research, National Cancer Institute, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA. |
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| Abstract: | Poecillastrin A (1), a new polyketide-derived macrolide lactam, was isolated from a deep-water collection of the marine sponge Poecillastra species. The structure of poecillastrin A (1) was assigned using NMR data acquired at 500 MHz with an inverse-detection cryogenic probe and at 800 MHz with a room-temperature probe. |
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