Direct catalytic enantioselective alpha-aminomethylation of aldehydes |
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Authors: | Ibrahem Ismail Zhao Gui-Ling Córdova Armando |
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Affiliation: | Department of Organic Chemistry, The Arrhenius Laboratory, Stockholm University, Stockholm, Sweden. |
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Abstract: | The direct catalytic asymmetric alpha-aminomethylation of aldehydes is presented. The chiral amine and amino acid catalyzed reactions between unmodified aldehydes and a formaldehyde-derived imine precursor were fast and proceeded with high chemo- and enantioselectivities. The corresponding dibenzyl-protected gamma-amino alcohols were isolated in high yields with up to 98% ee after in situ reduction. The reaction is a novel entry to valuable beta(2)-amino acid derivatives. |
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Keywords: | alpha‐aminomethylation aldehydes amino acids asymmetric catalysis diarylprolinol |
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