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Cost-effective flow injection spectrophotometric assay of iron content in pharmaceutical preparations using salicylate reagent |
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| Authors: | Udnan Y Jakmunee J Jayasavati S Christian G D Synovec R E Grudpan K |
| Affiliation: | a Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand b Institute for Science and Technology Research and Development, Chiang Mai University, Chiang Mai 50200, Thailand c Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand d Department of Chemistry, University of Washington, Box 351700, Seattle, WA 98195-1700, USA |
| Abstract: | A new flow injection procedure for an assay of Fe(III) by using salicylate obtained from antipyretic powder, which is a cheap and easily available reagent, is proposed. A red complex was continuously monitored by a laboratory-made green LED colorimeter. A linear calibration was obtained in the range of 1–20 mg Fe l−1 with a detection limit of 0.5 mg Fe l−1 and R.S.D.s of 1.4–5.4% (n=3, for 1–20 mg Fe l−1). The new procedure was applied to assay iron contents in pharmaceutical preparations. The results were in good agreement with those of the USP standard method. |
| Keywords: | Drugs Flow injection Iron Salicylate Aspirin |
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