Tandem [5+1] annulation-isocyanide cyclization: efficient synthesis of hydroindolones |
| |
Authors: | Wang He Zhao Yu-Long Ren Chuan-Qing Diallo Aboubacar Liu Qun |
| |
Institution: | Department of Chemistry, Northeast Normal University, Changchun 130024, China. |
| |
Abstract: | A new strategy for the rapid construction of functionalized reduced indoles starting from activated methylene isocyanides and 1,5-dielectrophilic 5-oxohepta-2,6-dienoates (and their equivalents) through a 5+1] annulation-isocyanide cyclization cascade under basic conditions has been developed. This strategy allows the synthesis of polysubstituted dihydroindolones and tetrahydroindolones in high to excellent yields under extremely mild conditions in a single step. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|