Automated quantitative gait analysis in animal models of movement disorders |
| |
| Authors: | Caroline Vandeputte Jean-Marc Taymans Cindy Casteels Frea Coun Yicheng Ni Koen Van Laere and Veerle Baekelandt |
| |
| Institution: | (1) Division of Nuclear Medicine, K.U. Leuven, Leuven, Belgium;(2) Laboratory for Neurobiology and Gene Therapy, Molecular Medicine, K.U. Leuven, Belgium;(3) Department of Radiology, K.U. Leuven, Leuven, Belgium |
| |
| Abstract: | Background Accurate and reproducible behavioral tests in animal models are of major importance in the development and evaluation of new
therapies for central nervous system disease. In this study we investigated for the first time gait parameters of rat models
for Parkinson's disease (PD), Huntington's disease (HD) and stroke using the Catwalk method, a novel automated gait analysis
test. Static and dynamic gait parameters were measured in all animal models, and these data were compared to readouts of established
behavioral tests, such as the cylinder test in the PD and stroke rats and the rotarod tests for the HD group. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
