Anaesthesia generates neuronal insulin resistance by inducing hypothermia |
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Authors: | Christian Holscher Lidy van Aalten Calum Sutherland |
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Institution: | (1) Biomedical Research Institute, University of Dundee, Ninewells Hospital, DD1 9SY Dundee, Scotland, UK;(2) School of Biomedical Sciences, University of Ulster, BT52 1SA Coleraine, Northern Ireland, UK |
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Abstract: | Background Anaesthesia is commonly employed prior to surgical investigations and to permit icv injections in rodents. Indeed it is standard
practise in many studies examining the subsequent actions of hormones and growth factors on the brain. Recent evidence that
the basal activity of specific intracellular signalling proteins can be affected by anaesthesia prompted us to examine the
effect of anaesthesia not only on the basal activity but also the insulin sensitivity of the major insulin signalling pathways. |
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