| NMR在天然产物选择性分离与结构研究中的应用 |
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| 引用本文： | 耿珠峰,欧阳捷,邓志威,沈圣民,杜树山.NMR在天然产物选择性分离与结构研究中的应用[J].波谱学杂志,2009,26(3):424-436. |
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| 作者姓名： | 耿珠峰 欧阳捷 邓志威 沈圣民 杜树山 |
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| 作者单位： | 1.北京师范大学 分析测试中心， 北京 100875；2.北京师范大学 资源学院教育部资源药物工程研究中心，北京 100875 |
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| 摘 要： | 核磁共振(NMR)是天然产物化学研究的重要手段. 本工作将核磁共振技术作为选择性提取分离的监测手段，依据目标化合物的NMR谱学特征，以1H NMR监控和指导从植物体中寻找和得到二萜类化合物收到了较好的效果. 并运用多种核磁共振技术对分离得到的3种二萜类化合物(jolkinolide A、jolkinolide B和17-hydro-xyjolkinolide B)进行了结构解析.
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| 关 键 词： | 核磁共振（NMR） 选择性分离 结构解析 天然产物 |
| 收稿时间： | 2009-05-14 |
| 修稿时间： | 2009-05-22 |
NMR Application in Selective Separation for Natural Products and Their Structural Investigation |
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| GENG Zhu-feng,OUYANG Jie,DENG Zhi-wei,SHEN Sheng-min,DU Shu-shan.NMR Application in Selective Separation for Natural Products and Their Structural Investigation[J].Chinese Journal of Magnetic Resonance,2009,26(3):424-436. |
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| Authors: | GENG Zhu-feng OUYANG Jie DENG Zhi-wei SHEN Sheng-min DU Shu-shan |
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| Institution: | 1.Analytical and Testing Center, Beijing Normal University, Beijing 100875, China；2.Beijing Normal University, College of Resources Science and Technology, Center for Natural Medicine Engineering, Ministry of Education, Beijing 100875, China |
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| Abstract: | NMR has played an important role in Natural Product Chemistry. In this work, NMR technique was used as a valid monitor in the separation process of natural products, in addition to its application in the structural elucidation of natural compounds. In the selective separation of diterpenoid-like compounds from the natural plants, 1H NMR was performed in time after each step of the separation. Combining with the knowledge about the spectral characteristics of the target compounds, the information obtained from 1H NMR spectra was well used to handle the separation work. |
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| Keywords: | NMR selective separation structural elucidation natural product |
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