5-去氮嘌呤核糖核苷类似物的设计与合成研究进展

综述了近年来有关5-去氮嘌呤核糖核苷类似物作为潜在生物活性(如抗病毒、抗肿瘤等)先导化合物的设计与合成研究进展.指出该类先导物的设计与合成主要基于以下两种途径:一是在去氮嘌呤碱基的4-位或5-位引入不同的取代基;二是在去氮嘌呤碱基的4-位或5-位引入不同取代基的同时,对核苷中的糖基进行修饰.并从这两种途径着手介绍了近年来该领域所取得的主要研究进展.

Progress in the design and synthesis of novel 5-deazapurine ribonucleosides

A review is provided of the research progress in the design and synthesis of novel 5deazapurine ribonucleosides as potential bioactive（such as antivirus and anticancer）lead compounds.It is pointed out that the design and synthesis of this kind of lead compounds usually rely on two routes：the introduction of different substituents in 4-substituted and 5-substituted positions of 5-deazapurines,and the introduction of different substituents in 4-substituted and 5-substituted positions of 5-deazapurines in association with simultaneous modification of sugar of nucleoside.The recent progresses in this field are briefed in relation to these two routes.