Total synthesis of crisamicin A |
| |
Authors: | Li Zhengtao Gao Yingxiang Tang Yefeng Dai Mingji Wang Guoxin Wang Zhigang Yang Zhen |
| |
Affiliation: | Laboratory of Chemical Genomics, Shenzhen Graduate School, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Beijing. |
| |
Abstract: | Stereoselective total synthesis of natural product crisamicin A (1) was accomplished for the first time via the Pd/TMTU-catalyzed alkoxycarbonylative annulation to generate a unique cis-pyran-fused lactone, an intermolecular Diels-Alder reaction to construct the pyranonaphthoquinone unit, and a novel Pd-thiourea pincer complex-catalyzed homocoupling of functionalized naphthoquinones. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|