Total synthesis of crisamicin A |
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| Authors: | Li Zhengtao Gao Yingxiang Tang Yefeng Dai Mingji Wang Guoxin Wang Zhigang Yang Zhen |
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| Affiliation: | Laboratory of Chemical Genomics, Shenzhen Graduate School, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Beijing. |
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| Abstract: | Stereoselective total synthesis of natural product crisamicin A (1) was accomplished for the first time via the Pd/TMTU-catalyzed alkoxycarbonylative annulation to generate a unique cis-pyran-fused lactone, an intermolecular Diels-Alder reaction to construct the pyranonaphthoquinone unit, and a novel Pd-thiourea pincer complex-catalyzed homocoupling of functionalized naphthoquinones. |
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