| 高效液相色谱法测定乳膏剂中的联苯苄唑 |
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| 引用本文： | 郭兴杰,魏宗有,李发美.高效液相色谱法测定乳膏剂中的联苯苄唑[J].色谱,2001,19(3):279-280. |
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| 作者姓名： | 郭兴杰 魏宗有 李发美 |
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| 作者单位： | 沈阳药科大学, |
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| 摘 要： | 用高效液相色谱法测定了乳膏剂中联苯苄唑的含量。色谱柱为HypersilODS(2 0 0mm× 4.6mmi.d .,5 μm) ,以 0 .0 8mol/L三乙胺磷酸盐缓冲液 (pH 7.0 ) 乙腈 甲醇 (体积比为 2 0∶10∶70 )为流动相 ,在 2 5 4nm波长处检测。联苯苄唑质量浓度在 8 99mg/L～ 44 96mg/L范围内 ,其浓度与其峰面积的线性关系良好 (r =0 .9998)。该法灵敏度较高 ,重现性好。
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| 关 键 词： | 高效液相色谱法 联苯苄唑 乳膏剂 |
| 文章编号： | 1000-8713(2001)03-0279-03 |
| 修稿时间： | 2000年9月20日 |
Determination of Bifonazole in Cream by High Performance Liquid Chromatography |
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| GUO Xing jie,WEI Zong you,LI Fa mei.Determination of Bifonazole in Cream by High Performance Liquid Chromatography[J].Chinese Journal of Chromatography,2001,19(3):279-280. |
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| Authors: | GUO Xing jie WEI Zong you LI Fa mei |
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| Institution: | Shenyang Pharmaceutical University, Shenyang 110015, China. |
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| Abstract: | An accurate method for the determination of bifonazole in cream is described. The analytical column was packed with Hypersil ODS. The mobile phase was a mixture of 0.08 mol/L aqueous triethylamine (TEA) phosphate solution(pH 7.0)-acetonitrile-methanol (20:10:70, V/V) and the detection wavelength was 254 nm. This method is simple, accurate and can be used for the quality control of bifonazole in cream. |
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| Keywords: | high performance liquid chromatography bifonazole cream |
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