Correlation with redox potentials and inhibitory effects on Epstein-Barr virus activation of azaanthraquinones |
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| Authors: | Koyama J Morita I Tagahara K Osakai T Hotta H Yang M X Mukainaka T Nishino H Tokuda H |
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| Affiliation: | Kobe Pharmaceutical University, Higashinada, Japan. j-koyama@kobepharma-u.ac.jp |
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| Abstract: | The redox potentials have been determined for nine azaanthraquinones in phosphate buffer at pH 7.2 by means of cyclic voltammetry. A definite correlation has been found between the redox potentials and the inhibitory effects of the azaanthraquinones on Epstein-Barr virus early antigen (EBV-EA) activation. It has further been shown that the correlation can be made better by introducing an electronic property, i.e., the atomic charge at O11 as an additional parameter. |
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