| 偏振同步光散射和同步光散射光谱区分与同时测定奎宁和奎尼丁对映异构体 |
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| 引用本文： | 赵小辉,王丹,杨季冬,贺薇,周尚,朱乾华,杨琼.偏振同步光散射和同步光散射光谱区分与同时测定奎宁和奎尼丁对映异构体[J].光散射学报,2013,25(1):66-72. |
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| 作者姓名： | 赵小辉 王丹 杨季冬 贺薇 周尚 朱乾华 杨琼 |
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| 作者单位： | 长江师范学院化学化工学院;中国石油集团石油职业卫生技术服务中心;重庆三峡学院 |
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| 基金项目： | 国家自然科学基金(21175015);教育部“春晖计划”项目(Z2009-1-63003);重庆市教委科技项目(kJ121306) |
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| 摘 要： | 在酸性缓冲溶液中,阴离子表面活性剂十二烷基苯磺酸钠SDBS能与金鸡纳类生物碱药物体系中一对对映异构体QN和QD作用产生增强的同步光散射(synchronous light scattering,SLS)信号,本文首先利用偏振同步光散射(polarized synchronous light scattering)信号,建立了同步光散射偏振度(P)区分QN和QD这对对映异构体,同时利用同步散射光谱和双标准曲线计量分析法对2种金鸡纳类生物碱药物进行同时测定,并将该方法应用于尿样中QN和QD的同时测定,结果令人满意。
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| 关 键 词： | 偏振同步光散射 同步光散射 奎宁 奎尼丁 SDBS 同时测定 |
| 收稿时间： | 2011/6/30 |
Discrimination and Simultaneous Determination of Quinine and Quinidine by Polarized Synchronous Light Scattering and Synchronous Light Scattering Spectrum |
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| ZHAO Xiao-Hui,WANG Dan,YANG Ji-Dong,HE Wei,ZHOU Shang,ZHU Qian-Hua,YANG Qiong.Discrimination and Simultaneous Determination of Quinine and Quinidine by Polarized Synchronous Light Scattering and Synchronous Light Scattering Spectrum[J].Chinese Journal of Light Scattering,2013,25(1):66-72. |
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| Authors: | ZHAO Xiao-Hui WANG Dan YANG Ji-Dong HE Wei ZHOU Shang ZHU Qian-Hua YANG Qiong |
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| Institution: | 1(1.School of Chemistry and Chemical Engineering,Yangtze Normal University, Chongqing 408000,China; 2.China National Petroleum Corporation Occupational Health Centre,Langfang 065000,China; 3.Chongqing Three Gorges University,Chongqing 404100,China) |
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| Abstract: | In acid buffer solution,anion surfactant SDBS could react with cinchona alkaloid drugs pair of enantiomers system QN and QD and resulted in a great enhacement of synchronous light scattering(SLS) signals.This article first established the degree of polarized synchronous light scattering(P) based on the measurements of the polarized synchronous light scattering signals to distinguish enantiomers system of QN and QD.Simultaneously based on the synchronous scattering spectrum and the double standard curve method,a novel method for simultaneous determination of QN and QD was developed by SLS spectralmethod.The method was applied to simultaneous determination of QN and QD in urine with satisfactory results. |
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| Keywords: | polarized synchronous light scattering synchronous light scattering quinine (QN) quinidine (QD) SDBS simultaneous determination |
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