Development of a quantitative structure-activity relationship model for inhibition of gram-positive bacterial cell growth by biarylamides |
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Authors: | Stanton David T Madhav Prakash J Wilson Larry J Morris Timothy W Hershberger Paul M Parker Christian N |
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Institution: | Health Care Research Center, Procter & Gamble Pharmaceuticals, 8700 Mason-Montgomery Road, Mason, Ohio 45040-9462, USA. stanton.dt@pg.com |
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Abstract: | A set of compounds consisting of a new and diverse collection of biarylamides was examined using quantitative structure-activity relationship techniques for the purpose of developing a model to describe inhibition of gram-positive bacterial growth (minimum inhibition concentration). The model was sought in order to obtain insight for designing new molecules. A detailed analysis of the underlying structure-activity relationship helped provide insight concerning which structural features of the molecules modulated the activity of the compounds against gram-positive organisms. |
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