| A Convenient and Easy-controlled Method for Preparation of 7,10-Bis（2,2,2-trichloroethyloxycarbonyl）-10-deacetyl Baccatin Ⅲ |
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| 作者姓名： | QIXin XULi LINXiao-ju JIYong WANGTian-wei |
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| 作者单位： | [1]SchoolofChemicalEngineering,DalianUniversityofTechnology,Dalian116012,P.R.China [2]InformationCollegeofScienceandTechnology,NanfingForestryUniversity,Nanjing210037,P.R.China [3]StateKeyLaboratoryofCoordinationChemistry,CoordinationChemistryInstitute,NanjingUniversity,Nanjing210093,P.R.China |
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| 基金项目： | Research Innovation Program of Nanjing Forestry University(No.CX0 3- 0 70 - 1) |
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| 摘 要： | The complex natural product paclitaxel (Taxol,la), first isolated from Taxus brevifolia,has an excellent clinical activity against ovarian and breast cancers and shows promising results in the treatment of other cancers. The structureactivity relationships (SAR) of taxoid derivatives have been extensively studied to search for the analogues bearing better physical, chemical and biological properties. One example is the discovery of
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| 关 键 词： | 2 2 2-三氯乙烷氯甲酸 10-脱乙酰基浆果赤霉素Ⅲ 简便合成 耦合反应 |
| 收稿时间： | 2003-12-22 |
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