Identification and enantioselective gas chromatographic mass-spectrometric separation of O-desmethylnaproxen,the main metabolite of the drug naproxen,as a new environmental contaminant |
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| Authors: | Stephanie Selke,Markus Scheurell,Muhammad Raza Shah,Heinrich Hü hnerfuss |
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| Affiliation: | 1. University of Hamburg, Institute of Organic Chemistry, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany;2. HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan |
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| Abstract: | O-Desmethylnaproxen (2-(6-hydroxynaphthalen-2-yl)propanoic acid) was identified in 10 different water samples from Germany and Pakistan. In the Pakistan samples it was found in all samples, surface water and effluents, exhibiting estimated concentrations between 0.04 and 1.36 μg/L. In Germany it was only encountered in the STP-effluent with an average concentration of 0.23 μg/L. Furthermore, enantioselective GC analyses revealed differences in the enantiomeric ratios found in Germany and Pakistan. To the best of our knowledge this is the first report on the identification of O-desmethylnaproxen, the main metabolite of the drug naproxen, in environmental samples. |
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| Keywords: | O-Desmethylnaproxen Naproxen PPCPs Enantioselective GC&ndash MS Karachi |
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