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Total Synthesis of an Experimental Antitubercular Drug CDRI-830 |
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| Authors: | Uma Reddy Pailla L K Ravindranath |
| Institution: | 1. Research and Development , Suven Life Sciences Ltd. , Hyderabad , India;2. Department of Chemistry , Sri Krishnadevaraya University , Ananthapur , Andhra Pradesh , India;3. Department of Chemistry , Sri Krishnadevaraya University , Ananthapur , Andhra Pradesh , India |
| Abstract: | The triarylmethane antituberculosis drug CDRI-830 is synthesized. The triarylmethane derivative 4 is prepared from ether 6 by a rearrangement process. The total synthesis of the drug CDRI-830 is achieved in a good overall yield of 35% from a simple thiophene derivative 8. |
| Keywords: | CDRI-830 ether rearrangement Friedel–Crafts reaction |