A total synthesis of OSW-1 |
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| Authors: | Xue Jie Liu Peng Pan Yanbin Guo Zhongwu |
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| Institution: | Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, USA. |
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| Abstract: | A new and practical method was developed to synthesize OSW-1, a natural saponin with potent antitumor activities, from (+)-dehydroisoandrosterone, l-arabinose, and D-xylose on gram scale. The synthesis was achieved in 10 linear steps with an overall yield of 6.4% starting from (+)-dehydroisoandrosterone. |
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