Copper-catalyzed complete regio- and stereoselective cyclization of 1-aryl-3-sulfanyl-4-oxahepta-1,6-diynes triggered by alkynylation |
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Authors: | Yoshimatsu Mitsuhiro Sasaki Hitomi Sugimoto Yuko Nagase Yuya Tanabe Genzoh Muraoka Osamu |
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Affiliation: | Department of Chemistry, Faculty of Education, Gifu University, Yanagido 1-1, Japan. yoshimae@gifu-u.ac.jp |
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Abstract: | Copper(I)-catalyzed alkynylation-cyclization of 4-oxahepta-1,6-diynes 1 with a wide variety of terminal alkynes proceeded to give (3E,4Z)-3-(phenylsulfanylmethylene)-4-(2-propynylidene)tetrahydrofuran-2-yl]benzenes 2aa-he in high yields with complete regio- and stereoselectivity. |
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