Copper(I)-catalyzed asymmetric desymmetrization: synthesis of five-membered-ring compounds containing all-carbon quaternary stereocenters |
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Authors: | Aikawa Kohsuke Okamoto Tatsuya Mikami Koichi |
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Institution: | Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo 152-8552, Japan. |
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Abstract: | A highly stereoselective catalytic alkylation sequence for the synthesis of highly functionalized and versatile five-membered-ring compounds bearing all-carbon quaternary stereocenters was developed. Enantioselective desymmetrization of achiral cyclopentene-1,3-diones was thus executed by chiral Cu-phosphoramidite catalysts. A variety of complicated cyclopentane derivatives can be synthesized with excellent stereoselectivities using a low catalyst loading in a one-pot operation. |
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