Improved protocol for indoline synthesis via palladium-catalyzed intramolecular C(sp2)-H amination |
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| Authors: | He Gang Lu Chengxi Zhao Yingsheng Nack William A Chen Gong |
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| Institution: | Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA. |
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| Abstract: | An efficient method has been developed for the synthesis of indoline compounds from picolinamide (PA)-protected β-arylethylamine substrates via palladium-catalyzed intramolecular amination of ortho-C(sp(2))-H bonds. These reactions feature high efficiency, low catalyst loadings, mild operating conditions, and the use of inexpensive reagents. |
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