Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridines and related heterocycles by cobalt-catalyzed [2 + 2 + 2] cyclizations |
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| Authors: | Zhou Ya Porco John A Snyder John K |
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| Institution: | Department of Chemistry and the Center for Methodology and Library Development, Boston University, Boston, Massachusetts 02215, USA. |
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| Abstract: | reaction: see text] Microwave-promoted, cobalt-catalyzed intramolecular 2 + 2 + 2] cyclizations of dialkynylnitriles successfully gave 5,6,7,8-tetrahydro-1,6-naphthyridines. The efficient synthesis of these relatively simple, yet rarely addressed heterocycles enabled the preparation of a collection of these compounds. |
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