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Synthesis of olivanic acid analogues: a facile route to 3-(2-pyrimidinylthio-) substituted derivatives |
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| Authors: | Andrew J. G. Baxter Pamela Davis Roger J. Ponsford Robert Southgate |
| Affiliation: | Beecham Pharmaceuticals, Research Division, Brockham Park, Betchworth, Surrey, RH3 7AJ U.K. |
| Abstract: | 3-(2-Pyrimidinylthio-) substituted olivanic acid analogues, with and without a C-6 hydroxyethyl substituent, have been synthesised in high yield using an intramolecular Wittig reaction followed by deprotection to afford zwitterions with high antibacterial activity. |
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