| DSC and NMR Study on the Inclusion Complex of Lappaconitine with b-Cyclodextrin |
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| 引用本文： | Kai Jun LIAO,Xiao Hua YAN,Dong Yun ZHAO,Xue Yi MA* Department of Chemistry,National Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000. DSC and NMR Study on the Inclusion Complex of Lappaconitine with b-Cyclodextrin[J]. 中国化学快报, 2002, 0(3) |
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| 作者姓名： | Kai Jun LIAO Xiao Hua YAN Dong Yun ZHAO Xue Yi MA* Department of Chemistry National Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 |
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| 作者单位： | Kai Jun LIAO，Xiao Hua YAN，Dong Yun ZHAO，Xue Yi MA* Department of Chemistry，National Laboratory of Applied Organic Chemistry，Lanzhou University，Lanzhou 730000 |
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| 摘 要： | Lappaconitine (Figure 1) is a diterpenoid alkaloid, naturally occurring in roots and rhizomes of Aconitum and delphinium1. Lap reveals bradycardic and hypotensive activity2. But its application is restrained owing to its poor water solubility, toxicity and side effects on humans. In a number of pharmaceutical studies, b-CD has been reported to interact with many drug molecules to form inclusion complexes for improving the water solubility of drugs, and reducing their toxicity3. We have p…
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DSC and NMR Study on the Inclusion Complex of Lappaconitine with b-Cyclodextrin |
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| Kai Jun LIAO,Xiao Hua YAN,Dong Yun ZHAO,Xue Yi MA. DSC and NMR Study on the Inclusion Complex of Lappaconitine with b-Cyclodextrin[J]. Chinese Chemical Letters, 2002, 0(3) |
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| Authors: | Kai Jun LIAO Xiao Hua YAN Dong Yun ZHAO Xue Yi MA |
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| Affiliation: | Kai Jun LIAO,Xiao Hua YAN,Dong Yun ZHAO,Xue Yi MA* Department of Chemistry,National Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000 |
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| Abstract: | The inclusion complex of lappaconitine (Lap) with b-cyclodextrin (b-CD) has been studied by the differential scanning calorimetry (DSC) and 1H-NMR, 2D-NMR spectroscopy. The structure of the complex has been deduced. |
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| Keywords: | Aconitum delphinium lappaconitine b-cyclodextrin inclusion complex DSC NMR. |
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