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Mechanism insights into an unexpected isomerisation reaction observed during conversion of N-benzyl piperazinones to corresponding N-benzyl thio-piperazinones |
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| Authors: | Emanuele Miserazzi Mario Alessandro SpottiRoberto Profeta Simone SpadaArnaldo Nalin Elisa MoroDaniele Andreotti |
| Affiliation: | GlaxoSmithKline, Medicines Research Centre, Via A. Fleming 4, 37100 Verona, Italy |
| Abstract: | An interesting and surprising rearrangement was observed during the reaction of 4-N-benzyl piperazinone derivatives with Lawesson’s reagent as a thionating agent. Investigation into the possible mechanism responsible for these results is reported herein. |
| Keywords: | Lawesson reagent Thioamides N-Benzyl piperazinones Mechanism Red-Ox N-Benzyl thio-piperazinones |
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