A short synthesis of 4-amino-3-hydroxybutyric acid (GABOB) via allyl cyanide |
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Authors: | Mete E. Maraş A. Seçen H. |
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Affiliation: | (1) Department of Chemistry, Faculty of Arts and Sciences, Ataturk University, 25240 Erzurum, Turkey |
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Abstract: | 4-Amino-3-hydroxybutyric acid was synthesized from allyl cyanide in four steps in an overall yield of 38%. Ultrasonically promoted epoxidation of allyl cyanide with m-chloroperoxybenzoic acid giving oxiranylacetonitrile was used as a key step. |
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Keywords: | 4-amino-3-hydroxybutyric acid GABOB allyl cyanide epoxidation sonification azides |
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