Termination of (many) 4-dimensional log flips

We prove that any sequence of 4-dimensional log flips that begins with a klt pair (X,D) such that -(K _X +D) is numerically equivalent to an effective divisor, terminates. This implies termination of flips that begin with a log Fano pair and termination of flips in a relative birational setting. We also prove termination of directed flips with big K _X +D. As a consequence, we prove existence of minimal models of 4-dimensional dlt pairs of general type, existence of 5-dimensional log flips, and rationality of Kodaira energy in dimension 4.