Synthesis of optically active 9-purinyl-α-amino acids

A general method for the synthesis of optically active 9-purinyl--amino acids by condensation of 5-amino-4,6-dichloropyrimidine with ,-diamino carboxylic acids and subsequent cyclization of the N-(5-amino-4-chloro-6-pyrimidinyl)-amino acids with triethyl orthoformate was developed. A number of 6-substituted -amino--(9-purinyl) carboxylic acids were obtained by nucleophilic substitution of the chlorine atom in the -amino--(6-chloro-9-purinyl) carboxylic acids.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1690–1695, December, 1982.