New chiral crown ether stationary phase for the liquid chromatographic resolution of alpha-amino acid enantiomers |
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Authors: | Hyun M H Han S C Lipshutz B H Shin Y J Welch C J |
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Institution: | Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, South Korea. mhhyun@hyowon.cc.pusan.ac.kr |
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Abstract: | A new chiral stationary phase (CSP) for the liquid chromatographic separation of enantiomers was prepared by bonding a novel enantiopure (diphenyl-substituted 1,1'-binaphthyl) crown ether to 5 microm silica gel. The resulting CSP was applied to the separation of the enantiomers of various natural and unnatural alpha-amino acids. All alpha-amino acids tested were resolved very well on the new CSP, with the exception of proline, which does not contain a primary amino group. The resolution of alpha-amino acid enantiomers on this new CSP was found to be dependent on the type and amounts of organic and acidic modifiers, and on column temperature. |
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