Determination of lovastatin acid in serum by gas chromatography/mass spectrometry |
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| Authors: | D Wang-Iverson E Ivashkiv M Jemal A I Cohen |
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| Affiliation: | Squibb Institute for Medical Research, Analytical Research and Development, New Brunswick, New Jersey 08903. |
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| Abstract: | The acid form of lovastatin, an HMG-CoA reductase inhibitor, was analyzed by gas chromatography/negative-ion chemical ionization mass spectrometry after derivatization with pentafluorobenzyl bromide and bis-(trimethylsilyl)trifluoroacetamide (BSTFA). Mass spectrometry of this derivative produced a dominant [M-181]- ion under chemical ionization conditions using ammonia as the reagent gas. The limit of detection was approximately 2 pg injected on column. |
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