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Determination of lovastatin acid in serum by gas chromatography/mass spectrometry
Authors:D Wang-Iverson  E Ivashkiv  M Jemal  A I Cohen
Affiliation:Squibb Institute for Medical Research, Analytical Research and Development, New Brunswick, New Jersey 08903.
Abstract:The acid form of lovastatin, an HMG-CoA reductase inhibitor, was analyzed by gas chromatography/negative-ion chemical ionization mass spectrometry after derivatization with pentafluorobenzyl bromide and bis-(trimethylsilyl)trifluoroacetamide (BSTFA). Mass spectrometry of this derivative produced a dominant [M-181]- ion under chemical ionization conditions using ammonia as the reagent gas. The limit of detection was approximately 2 pg injected on column.
Keywords:
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