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| A New Synthesis Method and Crystal Structure of 2-Phenyl-5,6,7,8-tetrahydro-6,6-dimethyl-5,7-methano-8-quinolinol | |
| 作者姓名： | GAO Yong-Guangb MU Chu-Chunb LI Xin-Shenga b② XU Dong-Chenga b SU Honga WEN Yi-Hanga b a |
| 作者单位： | Department of Chemistry and Life Science Zhejiang Normal University，Department of Chemistry and Life Science，Zhejiang Normal University，Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces，Institute of Physical Chemistry，Zhejiang Normal University，Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces，Institute of Physical Chemistry，Zhejiang Normal University，Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces，Institute of Physical Chemistry，Zhejiang Normal University，Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces，Institute of Physical Chemistry，Zhejiang Normal University，Jinhua 321004，China，Jinhua 321004，China，Jinhua 321004，China，Department of Chemistry and Life Science，Zhejiang Normal University，Jinhua 321004，China，Jinhua 321004，China，Department of Chemistry and Life Science，Zhejiang Normal University，Jinhua 321004，China，Jinhua 321004，China，Jinhua 321004，China，Department of Chemistry and Life Science，Zhejiang Normal University，Jinhua 321004，China |
| 摘 要： | The title compound 2-phenyl,5,6,7,8-tetrahydro-6,6-dimethyl-5,7-methano-8- quinolinol 1 has been synthesized by the oxidation of corresponding anion with 02. The oxidation gave a convenient method for synthesizing pyridylalcohol 1 in good yield. The suitable single crystals for X-ray diffraction were obtained by recrystallization from a mixture of solvents （ether and ethyl acetate）. The configuration of C6 in the title compound is in R form and there are strong face-to-face offset π-π interactions between pyridine rings. Crystallographic data for 1： C18H19NO, Mr = 265.34, monoclinic, space group P21/c with a = 13,4073（4）, b = 10.2866（3）, c = 10,5570（3）A, β = 108.413（2）°, V = 1381.43（7） A^3, Z = 4, De= 1.276 g/cm^3, μ = 0.078 mml, F（000） = 568, R = 0.0721 and wR = 0.2054 for 2241 observed reflections （I〉 2σ（I））. |
| 关 键 词： | 合成 晶体结构 吡啶乙醇 杂环化合物 |
A New Synthesis Method and Crystal Structure of 2-Phenyl-5,6,7,8- tetrahydro-6,6-dimethyl-5,7-methano-8-quinolinol |
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| GAO Yong-Guang,MU Chu-Chun,LI Xin-Sheng,XU Dong-Cheng,SU Hong,WEN Yi-Hang.A New Synthesis Method and Crystal Structure of 2-Phenyl-5,6,7,8-tetrahydro-6,6-dimethyl-5,7-methano-8-quinolinol[J].Chinese Journal of Structural Chemistry,2008,27(6):663-666. | |
| Authors: | GAO Yong-Guang MU Chu-Chun LI Xin-Sheng XU Dong-Cheng SU Hong WEN Yi-Hang |
| Institution: | 1. Department of Chemistry and Life Science, Zhejiang Normal University, Jinhua 321004, China 2. Zhefiang Key Laboratory for Reactive Chemistry on Solid Surfaces, Institute of Physical Chemistry, Zhejiang Normal University, Jinhua 321004, China;Department of Chemistry and Life Science, Zhejiang Normal University, Jinhua 321004, China 3. Zhefiang Key Laboratory for Reactive Chemistry on Solid Surfaces, Institute of Physical Chemistry, Zhejiang Normal University, Jinhua 321004, China |
| Abstract: | The title compound 2-phenyl-5,6,7,8-tetrahydro-6,6-dimethyl-5,7-methano-8-quinolinol 1 has been synthesized by the oxidation of corresponding anion with O2. The oxidation gave a convenient method for synthesizing pyridylalcohol 1 in good yield. The suitable single crystals for X-ray diffraction were obtained by recrystallization from a mixture of solvents (ether and ethyl acetate). The configuration of C6 in the title compound is in R form and there are strong face-to-face offset π-π interactions between pyridine rings. Crystallographic data for 1: C18H19NO, Mr = 265.34, monoclinic, space group P21/c with a = 13.4073(4), b = 10.2866(3), c = 10.5570(3) (A),β = 108.413(2)°, V= 1381.43(7) A3, Z = 4, Dc= 1.276 g/cm3, μ = 0.078 mm-1, F(000) = 568, R =0.0721 and wR = 0.2054 for 2241 observed reflections (Ⅰ>2σ(Ⅰ)). |
| Keywords: | pyridylalcohol synthesis crystal structure |
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