Reaction of 1-methyluracil with phenylbenzhydrazonoyl chloride |
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Authors: | N B Chernyshova V N Shibaev |
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Institution: | (1) N. D. Zelinskii Institute of Organic Chemistry, Moscow |
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Abstract: | The ambident anion of 1-methyluracil gives with phenylbenzyhydrazonoyl chloride, depending on the conditions, the N-acylation product (polar solvent, room temperature), or the O-acylation product (nonpolar solvent, heating), which rearranges to a cytosine derivative. Convenient methods have been developed for the preparation of 6-methyl-1,3-diphenyl-5,6-dihydro-5-oxopyrimido4,3-c]triazolium chloride, a fluorescent derivative of 1-methyluracil, from the N-acylation product, and for the rapid base cleavage of the uracil ring under very mild conditions.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 649–655, May, 1986. |
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