N-Methylative aziridine ring opening and asymmetric synthesis of MeBmt |
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| Authors: | Yongeun KimDoo-Ha Yoon Hyun-Joon Ha Kyung Yeon KangWon Koo Lee |
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| Affiliation: | a Department of Chemistry and Protein Research Center for Bio-Industry, Hankuk University of Foreign Studies, Yongin, Kyunggi-Do 449-719, Republic of Korea
b Department of Chemistry, Sogang University, Seoul 121-742, Republic of Korea |
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| Abstract: | Asymmetric synthesis of MeBmt, an unusual amino acid constituent of cyclosporine A, was achieved from aziridine-(2R)-carboxaldehyde through the highly stereoselective addition of (E)-crotylboronate and the subsequent N-methylative aziridine ring opening as key steps. |
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| Keywords: | MeBmt Asymmetric synthesis Aziridine Ring opening Crotylation |
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