Prevention and mechanism effect of Zn(II) coordination complex on oral implant restoration |
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| Authors: | Lei Huang Zhili Qiu Shu Wang |
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| Institution: | 1. Department of Stomatology, Taizhou Municipal Hospital, Taizhou, Zhejiang, China;2. Zhejiang Taizhou White -Collar Dental, Taizhou, Zhejiang, China |
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| Abstract: | In this study, by reaction of Zn(NO3)2·6H2O with HL ligand under a slow evaporation reaction condition, a novel mononuclear Zn(II) complex Zn(L)2]·C2H5OH (1) with tetrahedral coordination geometry has been created by employment of an adamantan-type Schiff-base ligand 2-(adamantan-1-ylimino)methyl-4-methylphenol (HL). Its application values against the recurrent infection after oral implants were evaluated with ELISA assay and real time RT-PCR assay. The Zn(II) complex toxicity was evaluated in this research with CCK-8 assay. The molecular docking simulation confirmed that the adamantane functional group applied a hindrance effect on the connected nitrogen atom and therefore, the oxygen atom on the hydroxyl functional group could form binding interaction with receptor as expected. |
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| Keywords: | Coordination complex Oral implant restoration Toxicity Molecular docking |
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