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Treatment effects and mechanisms of Cu(II) coordination polymer in hypotension after anesthesia
Authors:Shu-Liang Wang  Huan Wang  Yu Lan
Institution:Department of Anesthesiology, Hainan Western Central Hospital, Danzhou, Hainan, China
Abstract:A Cu(II) coordination polymer (CP) (that is, Cu2(OH)(H2O)2(cbca)·2H2O]n (1)) has been obtained with the reaction between Cu(II) salt and 4′-(1-carboxyethoxy)-1,1′-biphenyl]-3,5-dicarboxylic acid (H3cbca), a semi-rigid tricarboxylic acid ligand under the hydrothermal reaction condition. Prevention activity of the new compound on hypotension after anesthesia surgery was evaluated and the related mechanism was researched at the same time. The noninvasive blood pressure monitor was firstly conducted to measure the blood pressure of the animal after compound treatment. Besides, the real time RT-PCR assay was also used to determine theα receptor relative expression on vascular endothelial cells after compound treatment.
Keywords:Coordination polymer  Cu(II) complex  Hypotension  Anesthesia
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