Crystal feature and spectral characterization of Zn(II) complexes containing Schiff base of Acylpyrazolone ligand with antimalarial action |
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Authors: | Irfan Shaikh Maitrey Travadi RN Jadeja Ray J Butcher Jignesh H Pandya |
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Institution: | 1. Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, 390002, India;2. Department of Inorganic & Structural Chemistry, Howard University, Washington, DC, 22031, USA;3. D. K. V. Arts and Science College, Jamnagar, Gujarat, India |
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Abstract: | With association of acylpyrazolones and benzhydrazide, two novel Ligands BZ-PCBMCPMP ((Z)-N'-((4-chlorophenyl) (1-(3-chlorophenyl) 3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene) methyl) benzohydrazide) and BZ-PCBPMP ((Z)-N'-((4-chlorophenyl) (1-phenyl) 3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene) methyl) benzohydrazide)) with different O–N–O fashion were synthesized via Schiff base reaction, which on complexation with Zn(II) acetate dihydrate yields novel Zn(BZ-PCBMCPMP)2] and Zn-(BZ-PCBPMP)2] complexes with distorted octahedron framework. Structure elucidation was performed through several spectroscopic techniques such as FTIR, 1H-NMR, 13C NMR, TG-DTA, UV/Vis, and Single-crystal XRD. The non-electrolytic nature was confirmed through molar-conductance values. Single crystal X-ray study of the BZ-PCBPMP ligand shows intramolecular as well as intermolecular hydrogen bonding, giving rise to a H-bonded dimer. In Zn-(BZ-PCBPMP)2] one ligand is symmetrically coordinating while the other is asymmetrically coordinating to the Zinc atom. Antimalarial property of ligands and complexes was also discovered by its efficient MIC activity against Chloroquine sensitive P. falciparum. |
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Keywords: | Schiff base Pyrazolone Benzohydrazide Distorted octahedron Antimalarial MIC activity |
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