| 司帕沙星与卤素反应产物的荧光特性及其应用 |
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| 引用本文： | 杜黎明,范哲锋,郭全娥.司帕沙星与卤素反应产物的荧光特性及其应用[J].分析化学,2001,29(3):249-252. |
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| 作者姓名： | 杜黎明 范哲锋 郭全娥 |
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| 作者单位： | 山西师范大学分析测试中心 |
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| 摘 要： | 研究了卤素（F，Cl,Br,I)与喹诺酮类药物司帕沙星反应产物的荧光特性，发现在酸性介质中，亚硝酸可氧化司帕沙星继而被卤素取代，所得产物具有强烈的荧光发射，其荧光强度随着卤素原子半径的增大呈现规律的增强效应。司帕沙星卤代物荧光较司帕沙星强58－151倍。据此建立了卤素增强荧光光谱测定司帕沙星的新方法。该方法用于直接测定尿液中司帕沙星的含量，结果令人满意。本文还对司帕沙星的荧光增敏机理进行了探讨。
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| 关 键 词： | 司帕沙星 荧光光谱法 卤素 尿液 药物分析 抗菌剂 反应产物 荧光特性 |
Fluorescence Property of Reaction Productsof Sparfloxacin with Halide and Its Application |
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| Du Liming,Fan Zhefeng,Guo Quan′e.Fluorescence Property of Reaction Productsof Sparfloxacin with Halide and Its Application[J].Chinese Journal of Analytical Chemistry,2001,29(3):249-252. |
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| Authors: | Du Liming Fan Zhefeng Guo Quan′e |
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| Abstract: | The fluorescence characteristics of reaction products of sparfloxacin with halide (F, Cl, Br, I) have been studied. It was found that sparfloxacin was oxidized by nitrous acid then reacted with halide further to formstrong fluorescence substances in acid media. Their fluorescence intensitites enhanced with aggrandizing of atom radii of halides, which could emit the strong fluorescence 58～151 fold more than that of sparfloxacin itself. Thus a new sensitive method for the direct determination of sparfloxacin in human urine by derivative-synchronous fluorescence was presented. A plausible mchanism was proposed to explin this behavior. |
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| Keywords: | Sparfloxacin nitrous acid fluorescence spectra |
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